He served as a visiting scholar at multiple institutions, including Polish Academy of Science (Poland), University of Sao Paulo (Brazil), National Tsinghua University (Taiwan), the University of Tokyo (Japan), and EXPEC Advanced Research Center at Saudi Aramco (Saudi Arabia). *,A 3D Printed Microfluidic Perfusion Device for Multicellular Spheroid Cultures, 2017,Biofabrication, Ong, L.J.Y., Chong, L.H., Jin, L., Singh, P.K., Lee, P.S., Yu, H., Ananthanarayanan, A., Leo, H.L.,Toh, Y.C. Fluid shear stress primes mouse embryonic stem cells for differentiation in a self-renewing environment via heparan sulfate proteoglycans transduction, 2011,FASEB Journal, 25: 1208-1217, Toh, Y.C., Blagovi, K. and Voldman, J., 2010. This paper reports a double nuclear-staining technique in combination with confocal image processing to visualize and quantify cell viability in microfluidic 3D tissue constructs. This paper reports a rapid and simple method of fabricating integrated microfluidic devices with direct ink write (DIW) 3D printer. Integrating sensitive quantification of hepatic metabolic functions by capillary electrophoresis with laser-induced fluorescence detection, 2008,Analyst, 133: 326-330, Wen, F., Chang, S.,Toh, Y.C., Arooz, T., Zhuo, L., Teoh, S.H. A Configurable 3D Microenvironment in a Micro-fluidic Channel forPrimary Hepatocytes Culture. *, Leo, H.L. This kit was designed with modular components (i.e., each component followed a standardized unit) to achieve (1) customizability (users can easily reconfigure various components to comply with their experiments), (2) forward compatibility (new parts with the standardized unit can be designed and easily interfaced to the current kit), and (3) easy replacement of the parts experiencing wear and tear. She is passionate about understanding the properties of different types of materials and how they can be applied to the domain of living or biological systems. and Yu, H., 2013. Application of polyelectrolyte complex coacervation to improve the seeding efficiency of bone marrow stromal cells in 3D scaffolds. You can also collaborate with Pioneering Minds on patents within various categories of emerging fields like AI, Space Exploration, Nanomaterials, Autonomous Vehicles, DNA Editing, Robotics, IOT, Quantum Computing, Wearables, 3D Printing, Cryptocurrency, Energy Storage, Neurophotonics and other. and Yu, H., 2008. Featured in Global Medical Discovery(ISSN 1929-8536),Featured in Global Medical Discovery (ISSN 1929-8536), Jan 2013, Toh, Y.C., Blagovic, K., Yu, H. and Voldman, J., 2011. *, Substrate stiffness modulates the multipotency of neural crest derived human ectomesenchymal stem cells via CD44 mediated PDGFR signaling, 2018,Biomaterials167:153-167. Development of poly (lactic-co-glycolic acid)-collagen scaffolds for tissue engineering. We also discovered that substrate stiffness modulated the differentiation of NCSCs to eMSCs via a Rho-ROCK dependent pathway involving CD44-mediated inhibition of PDGFR signaling. This cost-effective, highly customizable pump kit should find use in lab-on-a-chip, organs-on-a-chip, and point-of-care microfluidic applications. This paper describes the fabrication of complex networks of microchannel via modularized stereolithography 3D printing. Featured in RSCs Chemical Biology, 2007, Issue 4Featured in RSCs Chemical Biology, 2007, Issue 4. The peristaltic pump kit exhibited good repeatability in flow rates and functioned for 7 days without any noticeable issues in performance. Lor Huai Chong, Huan Li, Isaac Wetzel, Hansang Cho, Yi-Chin Toh*, A liver-immune coculture array for predicting systemic drug-induced skin sensitization, 2018, Lab on a Chip 18: 3239. 2007,Lab on a Chip, 2007, 7: 681-694. Today I came across a new course Assembly Language by Making Games for Atari 2600 He is an elected Fellow of the American Institute for Medical and Biological Engineering (AIMBE), International Academy of Medical and Biological Engineering (IAMBE), Academy of Engineering, Singapore and the Singapore National Academy of Science. Louis Jun Ye Ong, Liang Zhu, Gabriel Jenn Sern Tan,Yi-Chin Toh*, Quantitative Image-Based Cell Viability (QuantICV) Assay for Microfluidic 3D Tissue Culture Applications, 2020,Micromachines, 11 (7): 10.3390/mi11070669. Cost-effective differentiation of hepatocyte-like cells from human pluripotent stem cells using small molecules. Toh, Y.C., Yen, J.J.L., Obbard, J.P. and Ting, Y.P., 2003. Cellular responses to a nanofibrous environment, 2006,NanoToday, 1(3): 34-43. Wen, F., Chang, S.,Toh, Y.C., Teoh, S.H. This paper discusses how microfluidic technologies can value add to the different phases of human microbiome research as well as the unique challenges that microfluidics must overcome when working with microbiome-relevant biological materials. Commercially available peristaltic pumps for microfluidics are usually bulky, expensive, and not customizable. You will receive a link to create a new password via email. Biomicrofluidics, 2020, 14, (5), DOI: 10.1063/5.0012185. Kim, L.,Toh, Y.C., Voldman, J. and Yu, H., 2007. Microfluidic systems for lab-on-a-chip (LoC) and organs-on-a-chip (OoC) applications require precise fluid flow control. and Yu, H., 2016. Yi-Chin Toh, Anju Raja, Hanry Yu, Danny van Noort, A 3D Microfluidic Model to Recapitulate Cancer Cell Migration and Invasion, 2018, Bioengineering, 5(2): 29, Live visualisation and tracking of breast cancer cells migrating across an ECM barrier in a microfluidic 3D tumor model, Srinivasan, A., Chang, S.Y., Zhang, S., Toh, W.S.,Toh, Y.C. The pumps exhibited good repeatability in flowrates and functioned inside a cell incubator (at 37C and 95 % humidity) for seven days without noticeable issues in the performance. Michinao Hashimoto is an Associate Professor at Singapore University of Technology and Design leading Soft Fluidics Group. Xianzhu Zhang, Dandan Cai, Feifei Zhou, Jie Yu, Xinyu Wu, Dongsheng Yu, Yiwei Zou, Yi Hong, Chunhui Yuan, Yishan Chen, Zongyou Pan, Varitsara Bunpetch, Heng Sun, Chengrui An, Yi-Chin Toh, Hongwei Ouyang, Shufang Zhang, Targeting downstream subcellular YAP activity as a function of matrix stiness with Verteporn-encapsulated chitosan microsphere attenuates osteoarthritis, 2020,Biomaterials, 232: 119724, Terry Ching, Yi-Chin Toh, Michinao Hashimoto, Fabrication of Complex 3D Fluidic Networks via Modularized Stereolithography, 2019, Advanced Engineering Materials, 1901109, https://doi.org/10.1002/adem.201901109. Recently I found a post on Facebook as a meme. His opinions and views on scientific issues and environmental policies have been, for example, covered in personal interviews, documentaries, and articles of National Geographic, BBC, PBS, FOX, Euronews, Discovery Channel, The Guardian, Huffington Post, Scientific American. degrees in Chemistry and Biochemistry/Biophysics from Oregon State University (2003), and Ph.D. degree from Harvard University (2009), followed by postdoctoral training at Massachusetts Institute of Technology and Childrens Hospital Boston. 2016,JoVE (Journal of Visualized Experiments), 112: pp.e54097-e54097. Toh, Y.C., Ho, S.T., Zhou, Y., Hutmacher, D.W. and Yu, H., 2005. Singapore University of Technology and Design (SUTD), Researchers developed DIY 3D-printed peristaltic pump kits for microfluidics, SHAKTI announces third silicon success with the Arduino-compatible Moushik, How do SSDs Work? Rapid customization of the instrument would benefit users. Being Restless and curious, I invested my time and solved it. She is also an aspiring photographer. The pump is powered and controlled by Arduino, an open-source electronics platform. To make microfluidic pumps more accessible to the scientific community, Singapore University of Technology and Design (SUTD) researchers have developed a highly-customizable and Arduino-powered peristaltic pump kit. Dibakar Mondal, Akshaya Srinivasan, Patricia Comeau, Yi-Chin Toh*, Thomas L Willett, Acrylated Epoxidized Soybean Oil / Hydroxyapatite-Based Nanocomposite Scaffolds Prepared by Additive Manufacturing for Bone Tissue Engineering, 2021, Materials Science & Engineering C, 118:111400. Before joining QUT, she led an independent research group as an Assistant Professor at the Department of Biomedical Engineering, National University of Singapore.
By evaluating NE tissue structural dysmorphia in the micropatterned NE model, we can successfully model gene- and drug-induced neurodevelopmental defects. In 2020, he joined Shrike Zhangs Laboratory at Harvard Medical School as a visiting research trainee, working on light-based 3D bioprinting. He is currently a Ph.D. Seep Arora, Akshaya Srinivasan, Chak Ming Leung,Yi-Chin Toh*, Bio-mimicking shear stress environments for enhancing mesenchymal stem cell differentiation, 2020, Current Stem Cell Research & Therapy, 15(5):414-427.
Scalable cell alignment on optical media substrates, 2013,Biomaterials,34(21): 5078-5087, Wang, Y.,Toh, Y.C., Li, Q., Nugraha, B., Zheng, B., Lu, T.B., Gao, Y., Ng, M.M.L. The pump is designed in the form of a kit, allowing end-users to customize the setup. 2005,Assay and Drug Development Technologies,3(2): 169-176. Moores Law is alive and well. Y.C. With an overarching research theme of microfluidics, the group works on various cross-disciplinary themes in biomedical engineering, digital fabrication, and food engineering. Our generation is blessed enough to leverage the advantage of Automation tools. Louis Jun Ye Ong, Terry Tsz Him Ching, Lor Huai Chong, Seep Arora, Huan Li, Ramanuj DasGupta, Po Ki Yuen, Yi-Chin Toh*, Self-Aligning Tetris-Like (TILE) Modular Microfluidic Platform for Mimicking Multi-Organ Interactions, 2019, Lab on a Chip,19, 2178-2191, 10.1039/C9LC00160C. Samper, D. van Noort, D.W. Hutmacher and H.Yu. In 2014 he was awarded the worlds most outstanding young researcher in materials science by the Bayer Foundation. Akshaya Srinivasan, Nelson Teo, Poon Kei Jun, Priya Tiwari, Akhilandeshwari Ravichandran, Wen Feng, Swee Hin Teoh, Thiam Chye Lim, Yi-Chin Toh*, Comparative Craniofacial Bone Regeneration Capacities of Mesenchymal Stem Cells Derived from Human Neural Crest Stem Cells and Bone Marrow, 2021, ACS Biomaterial Science and Research, 7, 1, 207221. Lor Huai Chong, Celine Ng, Huan Li, Edmund Feng Tian, Abhishek Ananthanarayanan, Michael McMillian, Yi-Chin Toh, Hepatic Bioactivation of Skin-Sensitizing Drugs to Immunogenic Reactive Metabolites, 2019,ACS Omega,4, 9, 13902-13912. Spatially organizedin vitromodels instruct asymmetric stem cell differentiation, 2011,Integrative Biology, 3: 1179-1187, Toh, Y.C., Kang, T.G., van Noort, D., Burkholder, B. and Zhang, J.B., 2011. Jyothsna joined The Fermart Lab in 2016 as NUS-SUTD PhD fellow. 2007,Materials Science and Engineering: C,27(2): 285292. By continuing you agree to the use of cookies. Advancing Stem Cell Research with microtechnologies: opportunities and challenges, 2010,Integrative Biology, 2: 305-325, Toh, Y.C., Lim, T.C., Tai, D., Xiao, G., van Noort, D. and Yu, H., 2009. Khong, S. Chang, V.D. | How does your Smartphone store data? #quantumcomputers. Please enter your username or email address. *, 2016. 2021 The Authors. *,A pump-free microfluidic 3D perfusion platform for the efficient differentiation of human hepatocyte-like cells, 2017,Bioengineering & Biotechnology. Geetika Sahni, Shu-Yung Chang1, Jeremy Teo Choon Meng, Jerome Zu Yao Tan, Jean Jacques Clement Fatien, Carine Bonnard, Kagistia Hana Utami, Puck Wee Chan, Thong Teck Tan, Umut Altunoglu, Hlya Kayserili, Mahmoud Pouladi, Bruno Reversade, Yi-Chin Toh*, A micropatterned human-specific neuroepithelial tissue for modeling gene and drug-induced neurodevelopmental defects, 2021, Advanced Science, https://doi.org/10.1002/advs.202001100. Javiers research at SUTD is focused on the broadstudy, development, and application of biological materials in science and technology. display: none !important;
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