However it appears urgent to organize an appropriate clinical trial (Bocci et al., 2010c) in order to evaluate whether an initial cycle, including 3248 treatments of well performed major AHT during 4 months can modify critical parameters including glycemic and C-reactive peptide levels, non-enzymatic glycosilation, aldose reductase activity, AGEs and the antioxidant-prooxidant balance. Morena M., Cristol J. P., Canaud B. Keane J., Gershon S., Wise R. P., Mirabile-Levens E., Kasznica J., Schwieterman W. D., Siegel J. N., Braun M. M. Tuberculosis associated with infliximab, a tumor necrosis factor alpha- neutralizing agent. Then after some 2530min, one is free to lay and relax in a warm bed for another half hour before having a shower and return to the normal life. The skin is no longer smooth and the patient may report slight pain during palpation. Szatrowski T. P., Nathan C. F. Production of large amounts of hydrogen peroxide by human tumor cells. The continuous generation of Reactive Oxygen Species (ROS) and of Lipid Oxydation Substances (LOPs); The formation of Advanced Glycosylation End substances (AGEs); The physiologic decline of circulating hormones; Oral administration of antioxidants and minerals. Administration of growth hormone (SC route) for 4 months (Slonim et al.. Cinnella P., Brayda-Bruno M. La nostra esperienza nel trattamento dei conflitti disco-radicolari e delle radicolopatie post-chirurgiche con ossigeno-ozono terapia infiltrativa paravertebrale. In conclusion, the probable mechanisms playing a role are the following: Most of the merit in developing the chemiodiscolysis with oxygen-ozone goes to Italian neurosurgeons and ortopedicians, who, by now, have probably successfully treated more than 30,000 patients. This is really the most simple and gentle therapeutic treatment able to recover most of the bodily functions. Bocci V., Paulesu L. Studies on the biological effects of ozone 1. Newsome D. A., Swartz M., Leone N. C., Elston R. C., Miller E. Oral zinc in macular degeneration. .z#dx/e%Md&.yNc\H'E#:(o~"MSE3aQ" Q:M#C6|5m1&\Y0&4Db:t{N |A"w)O2Gx"iB#WKRSW-54TdN}t'Rs2w!G\1*HdlQ=ifOPHuN5ptV,Emi>zv5,va8>#?AMDab!iqxZO!jy.Fz@YuCsq]=L9XK 5-DNLxE=4,0DOS/ KEkPw j9"%N #VNb[iejnpAy+skhYx^\[iNx"v4J,#'|bO$z&JrQlm" CpZ$]=MlO4M`O~B4zbMeXEqTt2V%K0@MT=w. Successively Cuban Authors have repeatedly shown that it is possible to induce the adaptation and a state of resistance to oxidative stress by preconditioning rats with ozone (via rectal route) for several days BEFORE the noxious stimulus (Len et al., 1998; Peralta et al., 1999; 2000; Borrego et al., 2004). Romero A., et al. It remains unclear how ozone acts. Second of two parts. Reduced superoxide dismutase in lung cells of patients with asthma. improves blood circulation and oxygen delivery to ischaemic tissues. corrects the endogenous chronic oxidative stress by upregulating the antioxidant system. Then, after 5min, we can open the ozonator line and allow a brief blood ozonation. Varro J. ber das Krebsproblem und seine Therapie, Ztschr. Poli G., Schaur R. J., Siems W. G., Leonarduzzi G. 4-hydroxynonenal: a membrane lipid oxidation product of medicinal interest. OReilly M. S., Boehm T., Shing Y., Fukai N., Vasios G., Lane W. S., Flynn E., Birkhead J. R., Olsen B. R., Folkman J. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Barnes P. J. Histone deacetylase-2 and airway disease. Ceballos-Picot I., Witko-Sarsat V., Merad-Boudia M., Nguyen A. T., Thvenin M., Jaudon M. C., Zingraff J., Verger C., Jungers P., Descamps-Latscha B. Glutathione antioxidant system as a marker of oxidative stress in chronic renal failure. Mecocci P., Polidori M. C., Troiano L., Cherubini A., Cecchetti R., Pini G., Straatman M., Monti D., Stahl W., Sies H., Franceschi C., Senin U. Under these circumstances, it is also difficult to envisage the optimal ozone dosages and schedules for performing ozone therapy. Liver histological results, whenever possible before and 3 months after the 6-month course. Bocci V. Autohaemotherapy after treatment of blood with ozone. The direct approach is carried out under radioscopic control: the needle is inserted in the centre of the pathologic intersomatic space just before direct insufflation of the gas mixture (Fig. A subtle inflammatory state with release of proinflammatory cytokines and platelet activation does further aggravate the process. If only we had enough money to pay ten volunteers and the testings, we could have answered this question a long time ago; indeed it would not be too difficult to evaluate, before and after ozonated autohaemotherapy, the complete hormonal pattern and cycling in the plasma throughout the day. Dreher D., Junod A. F. Role of oxygen free radicals in cancer development. When I visited Russian hospitals, I was told that they do not worry about it and use ozonetherapy to disinfect traumatic and war wounds, burns, radiation injuries and abdominal surgery after stomach or intestinal perforations. Only one patient of ours did it but its usefulness remains doubtful. Procure a state of well-being in patients by activating the neuro-endocrine system. The endocrinoly of aging. The chemistry of cell signalling by reactive oxygen and nitrogen species and 4-hydroxynonenal. e6)EIgf"{lf||U7$8GzR'F5'_)F]TH_rGetd|lF hV23dp",5g;p~Y7U?K The use of a placebo (simple autotransfusion or only oxygenated blood) would be interesting, but these patients are severely distressed and randomisation appears unethical. Vitmain C anatonizes the cytotoxic effects of antineoplastic drugs. There are a number of dermatological infections and burns that have been usefully treated by the combination of major and minor AHT as well as topical therapy with gas (when feasible) or with ozonated water and oil. It remains imperative that the ozonetherapist checks periodically his ozone generator and avoids injecting large volumes of gas. Ozonetherapy is not a superfluous treatment and is intended to complement and improve ordinary therapy, which, on its own, is insufficient to block the progression of the disease The case of emphysema is typical. The immunopathogenesis of sepsis. Although they cause a transitory (35min) pain, they usually elicit a diffuse analgesic effect after 58 infiltrations. Using a gradual increase of ozone concentrations (from low to medium: 2040 mcg/ml), we may achieve: adaptation to COS, hence a re-equilibration of the cellular redox state, which is a fundamental process for inhibting HIV replication. A., Barkhof F., Comi G., et al. It is becoming a sort of epidemic (Rocchini, 2002), and the OMS has projected a number of 350 millions in 2025. Bocci V., Brito G. S. Ozone therapy in critical patients. Extension of life-span by introduction of telomerase into normal human cells. Patterson C., Runge M. S. Therapeutic myocardial angiogenesis via vascular endothelial growth factor gene therapy: moving on down the road. Bocci V., Di Paolo N. Oxygen-ozone therapy in medicine: an update. The mucosal antigen barrier: cross talk with mucosal cytokines. Bressler N. M., Bressler S. B., Fine S. L. Age-related macular degeneration. Low back pain: which is the best way forward? He could not give information about the follow-up. Carmeliet P., Dor Y., Herbert J. M., Fukumura D., Brusselmans K., Dewerchin M., Neeman M., Bono F., Abramovitch R., Maxwell P., Koch C. J., Ratcliffe P., Moons L., Jain R. K., Collen D., Keshert E., Keshet E. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Greider C. W., Blackburn E. H. The telomere terminal transferaase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Ernst E., Cohen M. H. Informed consent in complementary and alternative medicine. Re R., Pellegrini N., Proteggente A., Pannala A., Yang M., Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. If I am correct, I am wondering how relevant the role of NOx generated with ozone is. Loprete F. Utilizzo dellossigeno-ozonoterapia nel trattamento della malattia varicosa e sue complicanze. He is a private ozonetherapist and cannot do a control but he has claimed to achieve total remission in about 60% of patients and partial improvement in 15%. 8600 Rockville Pike Brownlee M. A. Jaeschke H. Mechanisms of oxidant stress-induced acute tissue injury. They are not curative and have to be repeated if side effects are acceptable. With a few minutes of help by a kind relative adjusting perfectly the isolation around the neck (for absolutely avoiding breathing ozone!) Booth S., Wade R. Oxygen or air for palliation of breathlessness in advanced cancer. Clinical practice. Bocci V. Pu lOssigeno-Ozonoterapia migliorare la prognosi della bronco-pneumopatia cronica ostruttiva? Treatment for tinnitus included tricyclic antidepressants, which improved the symptom in 67% of the patients taking nortriptyline (Dobie et al., 1993). Rubin P., Hanley J., Keys H. M., Marcial V., Brady L. Carbogen breathing during radiation therapy-the Radiation Therapy Oncology Group Study. Weber W., Butcher J. It has been thought to solve this problem by using either creams or slow-release patches, which may be better than oral administration or injection. Moldofsky et al. Human longevit and IIp15.5: a study in 1321 centenarians. It is characterized by the formation of multiple lipomas, primarily present in the nape of the neck (Madelung collar) and in the supraclavicular, deltoid and abdominal regions. The second topic is less tragic, but no less serious. ), the enkephalinergic interneuron may inhibit the presynaptic connection of a neurocyte (c) of a spinal ganglion which, under compression of a herniated disc, stimulates the release of substance P (SP). Bocci V. Why orthodox medicine has not yet taken advantage of ozone therapy. Gladwin M. T., Schechter A. N., Shelhamer J. H., Pannell L. K., Conway D. A., Hrinczenko B. W., Nichols J. S., Pease-Fye M. E., Noguchi C. T., Rodgers G. P., Ognibene F. P. Inhaled nitric oxide augments nitric oxide transport on sickle cell hemoglobin without affecting oxygen affinity. Radu R. A., Mata N. L., Nusinowitz S., Liu X., Sieving P. A., Travis G. H. Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardts macular degeneration. Falm E. Angiogenesis inhibitor in clinical development; where are we now and where are we going? Holmboe E. S. Oral antihyperglycemic therapy for type 2 diabetes: clinical applications. Agostini, G., and Agostini, S., 1994, Contributo alla conoscenza e al trattamento della parmiculopatia edemato-fibro-sclerotica, in. Acquired and inherited lipodystrophies. The pathophysiology of these diseases is complex and characterized by the softening and even distruction of the articular cartilage, with increased matrix degradation due to collagenase and proteoglycanases. In other countries is rather unpopular because some patients do not accept the procedure and because, while one is certain of the ozone concentration and gas volume insufflated in the rectum-colon, nobody can be sure about the value of the really reacting ozone either eliminated with a flatulence or trapped by faeces and the luminal content. B., Higenbottam T. Caution with use of inhaled nitric oxide. 1st week: 20 mcg/ml for a total ozone dose of 4.50mg per treatment. The third, extremely important and paradoxical advantages is the adaptation to the small, calculated and therapeutic oxidative stresses induced by the ozone treatments. Three patients of group B (30%) showed good improvement. This treatment appears sufficient to kill all micro-organisms present in the PRCL and nobody has ever doubted the bactericidal potency of ozone. Particularly important is the protein denaturation and death of lactobacilli which, by normally acting on glucose, produce lactic acid favouring dental demineralization. in air (Head et al., 1997). Bocci V. Administration of interferon at night may increase its therapeutic index. Bocci V. Central nervous system toxicity of interferons and other cytokines. However, if the patient is already undergoing haemodialysis, can a well constructed programme of ozone therapy improve the quality of life, reduce morbidity and possibly delay mortality? Minokoshi Y., Kim Y. Biological approaches to mechanistically understand the healthy life span extension achieved by calorie restriction and modulation of hormones. Seddon J. M., Ajani U. Whenever possible we should use heparin as an anticoagulant because it enhances the release of IFN gamma. Sardinian centenarians as well as other groups have been studied: while gene polymorphism of cytokines plays an important role in inflammation do not affect life expectancy. I sensed that he had given us a good tip and I took him to the Pneumology Unit where the specialist, Dr. Maria Trusso, was bewildered by the result. The ozone treated group displayed a rise in arterial pO2 and a significantly reduced (by about 50%) frequency and severity of painful crises. I. Pharmacologic triggering of effector cells and the release of hydrogen peroxide. During the last decade, I often hoped to test this route in cancer patients but both oncologists and medical directors, hideously afraid of ozone toxicity, have always denied this possibility. In: Garaci E., Renzini G., Filadoro F., Goldstein A. L., Verhoef J., editors. The result is extensive intramedullary erythroid destruction and in any cases a short life span of the circulating erythrocytes. Nortvedt M. W., Riise T., Myhr K. M., Nyland H. I., Hanestad B. R. Type I interferons and the quality of life of multiple sclerosis patients. Extracorporeal blood oxygenation and ozonation (EBOO). The schedule of two treatments per week appears valid and well accepted by patients but, while we should start with a 225ml volume of blood and an ozone concentration of 20 mcg/ml, during a 4 week period, we should escalate the ozone concentration up to 5060 mcg/ml. Sarks J. P., Sarks S. H., Killingsworth M. C. Evolution of geographic atrophy of the retinal pigment epithelium. I have noticed that the pain at first elicited with an ozone concentration of 20 mcg/ml tends to subside because of a progressive elevation of the pain threshold. HO-I indirectly reduces vascular constriction because it suppresses the gene expression of endothelin-I and inhibits the proliferation of smooth muscle cells (Morita and Kourembanas, 1995; Duckers et al., 2001). Their progressive accumulation in noble tissues establish a vicious and self-propelled inflammatory loop (Galli, 2007). I mention these two compounds because they are specific inhibitors of NFKB, which allows the synthesis of IL-1 and TNF (Auphan et al.. Administration of aminoguanidine, or benfotiamine or carnosine have been suggested for blocking AGEss reactions. On the basis of the clinical improvement of ARMD and chronic limb ischemia patients (Mattassi et al., 1987; Romero Valdes et al., 1993; Tylicki et al., 2001; Giunta et al., 2001; Clavo et al., 2003) after only 2 months therapy, it is likely that 34 months therapy may bring about a normal oxygenation of the neoplastic tissues. The application of ozone as a good disinfectant in Dentistry is not surprising, but this is a new approach. (2008) have also pointed out that the available treatments, i.e., hydroxyurea, chronic transfusion and stem cell transplsnt are less than satisfactory. Wasser G. H. Zerebrale Durchblutungsstrungen. Liu H., Bravata D. M., Olkin I., et al. Giunta R., Coppola A., Luongo C., Sammartino A., Guastafierro S., Grassia A., Giunta L., Mascolo L., Tirelli A., Coppola L. Ozonized autohemotransfusion improves hemorheological parameters and oxygen delivery to tissues in patients with peripheral occlusive arterial disease. Low back-ache: conventional remedies versus ozone.
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